|
rs174547
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs2292832
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Previous studies have linked miRNA-149 to cancers, and rs2292832 T>C is related to allergic diseases and inflammatory bowel disease, which both show immune system disorders and coronary artery disease.
|
31785027 |
2019 |
|
rs3834458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
|
31781193 |
2019 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD.
|
31770616 |
2020 |
|
rs133049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The primary aim of this study was to investigate whether two leading ANRIL SNPs, namely, rs133049 and rs3217992, were associated with plasma levels of C-reactive protein among a large cohort of in-patients with CHD (n = 933).
|
31770616 |
2020 |
|
rs3217992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ANRIL polymorphisms (rs1333049 and rs3217992) in relation to plasma CRP levels among in-patients with CHD.
|
31770616 |
2020 |
|
rs756601757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We speculate that this mutation [Arg196Trp] in the USF1 gene might be associated with FCHL and early-onset coronary heart disease in this family.
|
31725952 |
2020 |
|
rs972655070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We speculate that this mutation [Arg196Trp] in the USF1 gene might be associated with FCHL and early-onset coronary heart disease in this family.
|
31725952 |
2020 |
|
rs761954844
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C308Y mutation in LDL-R results in approximately 70% loss of LDL-R activity, leading to the elevation of low density lipoprotein-cholesterol (LDL-C) and an increased risk of premature coronary heart disease (CHD).
|
31706281 |
2019 |
|
rs2910164
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A strong evidence indicated lack of association between rs2910164 in miR-146a and CHD.
|
31702616 |
2019 |
|
rs11614913
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Only rs11614913 was found to have significant associations with CHD.
|
31702616 |
2019 |
|
rs895819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Limited or conflicting evidences were found for the associations of the other variants (rs11134527, rs139365823, rs76987351, rs3746444, rs4938723, rs2292832, rs41291957, rs895819) and risk of CHD.
|
31702616 |
2019 |
|
rs1051338
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further, we characterized a second common exonic coding variant (rs1051339), which is predicted to alter LIPA signal peptide cleavage similarly to rs1051338</span>, yet is not linked to intronic variants. rs1051339 also does not impact LIPA function in vitro and confers no coronary artery disease risk.
|
31645127 |
2019 |
|
rs1051339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, we characterized a second common exonic coding variant (rs1051339), which is predicted to alter LIPA signal peptide cleavage similarly to rs1051338, yet is not linked to intronic variants. rs1051339 also does not impact LIPA function in vitro and confers no coronary artery disease risk.
|
31645127 |
2019 |
|
rs10159239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Single Nucleotide Polymorphism rs10159239 was examined by logistic regression with known risk factors for Coronary artery disease and remained significant (0.035).
|
31639433 |
2020 |
|
rs1743963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, both the GG genotype of <i>SGK1</i> rs1743963 and AA genotype of <i>SGK1</i> rs1763509 were associated with a higher risk of depression in CHD patients; for rs1763509, the Patient Health Questionnaire-9 (PHQ-9) scores in the carriers of the risk genotype for comorbid depression, AA, were significantly higher than in GG and AG carriers (<i>P</i> = 0.008).
|
31632443 |
2019 |
|
rs1763509
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, both the GG genotype of <i>SGK1</i> rs1743963 and AA genotype of <i>SGK1</i> rs1763509 were associated with a higher risk of depression in CHD patients; for rs1763509, the Patient Health Questionnaire-9 (PHQ-9) scores in the carriers of the risk genotype for comorbid depression, AA, were significantly higher than in GG and AG carriers (<i>P</i> = 0.008).
|
31632443 |
2019 |
|
rs9389154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It should be noted that only the significance of haplotype GGA survived after Bonferroni adjustment (<i>P</i> = 0.044) and that no significant differences were found for other <i>SGK1</i> SNPs (rs2758151, rs9493857, rs9376026, and rs9389154) between CHD patients with and without depression.
|
31632443 |
2019 |
|
rs2910164
|
|
|
0.070 |
GeneticVariation |
BEFREE |
After considering the heterogeneity of the global analysis, we inferred that rs2910164 polymorphisms were associated with a lower risk of coronary heart disease (CHD) significantly in all genetic models.
|
31626081 |
2019 |
|
rs2228671
|
|
|
0.730 |
GeneticVariation |
BEFREE |
We concluded that the heterozygosity in LDLR-rs72658855and rs2228671 and T allele in LDLR rs2228671are strongly associated with an increased susceptibility to coronary artery disease.
|
31613733 |
2020 |
|
rs72658855
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A non-significant association was reported in recessive inheritance model for variant (CC+CT) vs. TT OR 0.56(0.16-1.95), P<0.36. and in dominant inheritance model for variant CC vs. (CT+TT) OR 2.8(1.07-7.34),P<0.032 .In case of allelic comparison, it was indicated that the LDLR rs2228671-T allele was associated with an increased risk of developing risk of CAD compared to C allele OR=2.4, 95% CI (1.05-5.64) P< 0.036 .Our findings showed that LDLR rs72658855 C>T gene variability is associated with an increased susceptibility to coronary artery disease in codominant inheritance model for variant CC vs. CT OR 1.7(1.1-2.6), P<0.015 and in dominant inheritance model for variant CC vs. (CT+TT) OR 1.66(1.07-2.58),P<0.0.02.
|
31613733 |
2020 |
|
rs6265
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Plasma BDNF concentration, BDNF Val66Met polymorphism and other biological and anthropological risk factors for CHD were determined in 208 patients with CHD and 156 healthy controls.
|
31571628 |
2019 |
|
rs759834365
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Plasma BDNF concentration, BDNF Val66Met polymorphism and other biological and anthropological risk factors for CHD were determined in 208 patients with CHD and 156 healthy controls.
|
31571628 |
2019 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs1799983-T and rs891512-A alleles and interaction between rs1799983 and smoking were all risk factors of CHD.
|
31567371 |
2020 |
|
rs891512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1799983-T and rs891512-A alleles and interaction between rs1799983 and smoking were all risk factors of CHD.
|
31567371 |
2020 |